u call this function on button events
<button onclick="return isconfirm()" />
<script language=javascript>
function isconfirm()
{
var counter=0;
var obj=document.getElementById("<%=questionlist.ClientID%>").getElementsByTagName("input");
for(i=0;i<=obj.length-1;i++)
{
if(obj[i].type=="radio" && obj[i].checked==true)
{
counter++;
}
}
if(counter==0)
{ alert('Plz Select question Answer');
return false
}
return true;
}
</script>